Flcn autophagy
Tīmeklis2024. gada 21. marts · In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (PubMed: 31672913 ). Tīmeklis2024. gada 21. nov. · FLCN-FNIP1 is recruited to damaged mitochondria, and this process is inhibited in cells expressing RAB7AS72A. Moreover, nonphosphorylatable …
Flcn autophagy
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Tīmeklis2024. gada 28. okt. · The folliculin (FLCN) protein has been recently identified as a central regulatory node governing whole body energy homeostasis, and we … Tīmeklis2024. gada 1. maijs · Autophagy is an evolutionarily conserved intracellular homoeostatic process wherein cytoplasmic cargo-containing autophagosomes fuse with lysosomes to degrade the cargo 1.
TīmeklisThe causative gene, FLCN, is a tumor suppressor, which encodes folliculin (FLCN), a 64 kDa protein ( 22 ). Although little was known about FLCN function until recently, current studies have shown that FLCN may orchestrate a number of intracellular signaling pathways ( 23, 24 ). Tīmeklis2024. gada 11. sept. · FLCN’s best described function to date is involved in autophagy regulation. Loss of FLCN Loss of FLCN prevents mTORC1 localization on the lysosome surface and subsequently induces autophagy [62–
TīmeklisLC3 and GABARAP members of the ATG8 protein family are required for selective autophagy and sensing perturbation within the endolysosomal system. Here, we … Tīmeklis2024. gada 7. febr. · FLCN has been shown to regulate various signaling pathways and cellular metabolism through mTOR, AMPK, HIF1α, ciliogenesis, autophagy, and lysosomal biogenesis 30,46.
Tīmeklis2013. gada 4. dec. · Our results indicated that autophagy induced by paclitaxel in FLCN-null renal cancer cells plays a protective role, and the inhibition of autophagy could increase apoptosis induced by paclitaxel treatment in these cancer cells. Materials and methods Reagents and antibodies
Tīmeklis2024. gada 18. marts · FLCN is the gene associated with the Birt-Hogg-Dubé neoplastic syndrome in humans, characterized by predisposition to renal cell carcinoma, skin … list of chubb insurance subsidiariesTīmeklis2024. gada 20. apr. · The autophagy-lysosomal degradation system has an important role in maintaining liver homeostasis by removing unnecessary intracellular … list of chuck episodesTīmeklis2014. gada 22. jūl. · Folliculin (FLCN), the protein product of the FLCN gene, is a poorly characterized tumor suppressor protein, currently linked to multiple cellular … images of veterans dayTīmeklisCD51 + CD61 (Integrin alpha V + Integrin beta 3) CD51 / Integrin alpha V. CD52 list of chrysler bellhousing patternsTīmeklis2024. gada 1. okt. · Thus, the GABARAP-FLCN/FNIP-TFEB axis serves as a molecular sensor that coordinates lysosomal homeostasis with perturbations and cargo flux within the autophagy-lysosomal network. Discover the... images of vessels of honorTīmeklisFLcN is a positive driver of autophagy. (A) hK2 control and FLCN knockdown cells were transfected with the ptfMaP1Lc3B vector, fixed, and examined by confocal microscopy. Representative maximal Z-projection images of cells showing the RFP-GFP-MaP1Lc3B puncta are shown in the FLCN FLCN list of chuck e cheese charactersThe tumor suppressor gene FLCN encodes the protein folliculin, also known as Birt–Hogg–Dubé syndrome protein, which functions as an inhibitor of Lactate Dehydrogenase-A and a regulator of the Warburg effect. Folliculin (FLCN) is also associated with Birt–Hogg–Dubé syndrome, which is an … Skatīt vairāk Structure The FLCN gene consists of 14 exons. Location Cytogenetic location: The FLCN gene is located on the short (p) arm of chromosome 17 … Skatīt vairāk Interactions FLCN has been shown to interact through its C-terminus with two new co-chaperones folliculin … Skatīt vairāk • FLCN+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • The BHD Foundation Archived 2024-06-11 at the Wayback Machine supports … Skatīt vairāk • Schmidt LS, Linehan WM (October 2015). "Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome". Nature Reviews. … Skatīt vairāk list of chuck e cheese games