Firre lncrna
WebHere we show that the syntenically conserved lncRNA Firre displays distinct expression and localization patterns in human and mouse. Single molecule RNA FISH reveals that … WebApr 1, 2024 · The long-range chromatin interaction analyses identified a genomic region that interacts with the X-linked macrosatellite region, DXZ4.It is the Firre (Functional intergenic repeating RNA element) locus that abundantly produces the Firre lncRNA, primarily from the active X chromosome [40, 41 •]. Firre forms RNA clouds in the nucleus, and serves …
Firre lncrna
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WebSep 12, 2014 · It had long been suspected that RNA itself might be a key organizing factor that shapes this dynamic nuclear floor plan ( 1 ), with recent research pointing to a role for nuclear-retained long noncoding RNAs (lncRNAs) in organizing nuclear architecture. Here we provide a perspective on the classical and newly emerging role of RNA in this process. WebJan 26, 2014 · Here, we identify a long intergenic noncoding RNA (lincRNA), termed functional intergenic repeating RNA element (Firre), that localizes across a 5-Mb domain around its site of transcription. This...
WebTuberculosis is a worldwide contagion caused by Mycobacterium tuberculosis (MTB). MTB is characterized by intracellular parasitism and is semi-dormant inside host cells. The persistent inflammation caused by MTB can form a granuloma in lesion regions and intensify the latency of bacteria. In recent years, several studies have proven that long non-coding … WebFirre is a strictly nuclear lncRNA that interacts with the nuclear matrix protein hnRNPU, through a 156 bp repeat motif in its mature transcript sequence. This conserved and unique repeat motif, Repeating RNA Domain (RRD), is not only necessary to localize Firre around its site of transcription in the nucleus but also sufficient to act as a ...
WebNov 13, 2024 · Together, our results provide genetic evidence that the Firre locus produces a trans-acting lncRNA that has physiological roles in hematopoiesis. LncRNA loci potentially contain multiple...
WebMay 13, 2024 · Recent reports show that long noncoding RNA (lncRNA) FIRRE contributes to the proliferation, apoptosis resistance, and invasion of colorectal cancer and diffuse …
WebFeb 2, 2024 · Firre intergenic repeating RNA element (FIRRE), a lncRNA located in the nucleus, was overexpressed in colorectal cancer (CRC). However, the detailed … mesh teething ringWebObjectivesThe role of lncRNAs in gallbladder cancer (GBC) remains poorly understood. In this study, we explored the function of functional intergenic repeating RNA element … meshtec security screensWebRecently, a lncRNA, termed Firre, was identified as essential for adipocyte differentiation, and it displays a unique function in nuclear organization (136, 152, 153). Genetic deletion studies of Firre in embryonic stem cells showed that the lncRNA interacts with hnRNPU and mediates cross-chromosomal contacts between five chromosomes . meshtec security screen door installWebHacisuleyman et al. (2014) found that FIRRE is a lncRNA with a 156-bp repeating domain. They also identified numerous alternatively spliced transcripts with differential inclusion … how tall is elodie yungWebFurthermore, we demonstrate that Firre, a lncRNA highly enriched in the nucleoplasm and previously reported to mediate chromosomal contacts in ESCs, controls a network of genes related to RNA processing. Together, we provide a comprehensive, up-to-date, and high resolution compilation of lncRNA expression in ESCs and NPCs and show that nuclear ... mesh teething bagWebJun 30, 2024 · Firre encodes a lncRNA involved in nuclear organization in mammals. Here we find that Firre RNA is transcribed from the active X chromosome (Xa) and exerts trans-acting effects on the inactive X chromosome (Xi). how tall is elizabeth hurley and weightWebLncRNA-BATE10 is approximately 1.7 kb in length, contains 4 exons, and is located in an intergenic region of mouse chromosome 18. 32 Similar to lncRNA-BATE1, KD of lncRNA-BATE10 did not cause a significant difference in cell morphology, lipid accumulation, and expression of common lipid markers including PPARγ, CEBPα, and FABP4 during ... mesh teething feeder